Royal Air Force Typhoon FGR4s have operated alongside French warplanes in a combined operation against an subterranean weapons facility in Syria operated by the IS group, according to the British defence ministry.
The location, located using intelligence, was assessed as storing arms and explosives, the release indicated, and was positioned in mountainous terrain just above the ancient city of Palmyra in Syria's central region.
"The RAF jets employed laser-guided Paveway IV weapons to hit a number of entry passages down to the depot... early reports are that the target was engaged successfully," the MoD said.
There was no indication of any civilian impact in the attack conducted Saturday night and every plane involved returned safely, the ministry further stated.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
The Islamic State group - referred to as the so-called Islamic State - established militant control over significant areas in Iraq and Syria before its territorial defeat in 2019.
"This action underscores the UK's leading role, and determination to operate in unison with our allies, to stamp out any re-emergence of IS and their violent and radical beliefs in the region," UK Defence Secretary the Defence Secretary remarked.
British military aircraft have performed surveillance missions over Syria to "forestall any attempted resurgence" of the group subsequent to its routing at the battle of Baghuz in 2019, the ministry said.
"I want to thank every member of our armed forces participating in this mission for their skill and their bravery," he commented. "Including them were numerous British troops stationed over Christmas and New Year. This operation, to take out militants who pose a risk to our security, demonstrates how British military are prepared to act, continuously, keeping Britain secure at home and powerful internationally."
In December, the US military conducted what it described as a "large-scale strike" against Daesh sites in the country, subsequent to an ambush resulted in the deaths of two American soldiers and a civilian linguist in the Palmyra area.
The United Nations estimates Daesh still has between 5,000 and 7,000 combatants in both countries.